原创力文档application of a naturalistic psychogenic stressor in periadolescent mice effect on serum corticosterone levels differs by strain but not sex应用自然心因性压力源periadolescent小鼠血清皮质酮水平应变不同,但不影响性.pdfVIP
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application of a naturalistic psychogenic stressor in periadolescent mice effect on serum corticosterone levels differs by strain but not sex应用自然心因性压力源periadolescent小鼠血清皮质酮水平应变不同,但不影响性
Kapelewski et al. BMC Research Notes 2010, 3:170
/1756-0500/3/170
S HO RT REPORT Open Access
Short Report
Application of a naturalistic psychogenic stressor
in periadolescent mice: effect on serum
corticosterone levels differs by strain but not sex
Christine H Kapelewski, Jeanette M Bennett, Sonia A Cavigelli and Laura C Klein*
Abstract
Background: As a first step in determining whether psychogenic stressors might be incorporated into periadolescent
mouse models of stress, we evaluated whether a commonly used psychogenic stressor, exposure to red fox urine,
alters serum corticosterone levels in periadolescent C57BL/6J and DBA/2J mice.
Findings: In a 1-day experiment, forty-eight 38-day-old C57BL/6J (N = 12 males; N = 12 females) and DBA/2J (N = 12
males; N = 12 females) mice were exposed to 10-min of red fox urine via cotton ball (N = 12 C57BL/6J mice; N = 12
DBA/2J mice) or to a non-saturated cotton ball (N = 12 C57BL/6J mice; N = 12 DBA/2J mice). All mice were sacrificed
15-min after cotton ball exposure and serum was collected for corticosterone assessment. Overall, there was a main
effect for strain such that C57BL/6J male and female mice displayed higher corticosterone levels than did male and
female DBA/2J mice. There were no main effects for sex or odor exposure. However, there was a significant strain by
odor exposure interaction, whereby, within odor-exposed mice, DBA/2J mice displayed lower corticosterone levels
(ng/mL) compared to C57BL/6J mice, regardless of sex. Further, among DBA/2J mice, predator odor exposure reduced
corticosterone levels compared to no odor exposure.
Conclusions: Findings indicate that mouse strain, but not sex, may play an important role in the efficacy of a predator
odor among periadolescent mice.
Background
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