原创力文档appraisal of progenitor markers in the context of molecular classification of breast cancers祖标记鉴定的分子分类的乳腺癌.pdfVIP
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appraisal of progenitor markers in the context of molecular classification of breast cancers祖标记鉴定的分子分类的乳腺癌
Haviv Breast Cancer Research 2011, 13:102
/content/13/1/102
EDITORIAL
Appraisal of progenitor markers in the context of
molecular classii cation of breast cancers
Izhak Haviv*1-3
See related research by Keller et al., /content/12/5/R87
in the enrichment of TIC activities, including mammo-
Abstract spheres [6] and trans plan ta tion efficiency in mouse
Clinical management of breast cancer relies on case xenografts [7]. Establishing xeno graft growth could be
stratii cation, which increasingly employs molecular the product of several system-specifi c selections other
markers. The motivation behind delineating breast than breast progenitor phenotypes. However, further
epithelial dif erentiation is to better target cancer molecular profi ling of these cell populations – in which
cases through innate sensitivities bequeathed CD44+/CD24−/low-sorted cells expressed low levels of
to the cancer from its normal progenitor state. A luminal diff erentiation markers (such as MUC1, CD24,
combination of histopathological and molecular or CDH1) and elevated levels of epithelial-mesenchymal
classii cation of breast cancer cases suggests a role for transition markers (such as VIM, collagens, TWIST1,
progenitors in particular breast cancer cases. Although SNAI1/2, and Zeb1/2) – indicated a link between
a remarkable fraction of the real tissue repertoire epithelial-mesen chymal transi tion, TIC, and basal
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