assessing the power of tag snps in the mapping of quantitative trait loci (qtl) with extremal and random samples评估标记snp的力量在映射的数量性状位点(qtl)定位与极值和随机样本.pdfVIP

BMC Genetics BioMed Central Research article Open Access Assessing the power of tag SNPs in the mapping of quantitative trait loci (QTL) with extremal and random samples 1 2 Kui Zhang* and Fengzhu Sun* Address: 1Section on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA and 2Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA Email: Kui Zhang* - kzhang@; Fengzhu Sun* - fsun@ * Corresponding authors Published: 19 October 2005 Received: 08 June 2005 Accepted: 19 October 2005 BMC Genetics 2005, 6:51 doi:10.1186/1471-2156-6-51 This article is available from: /1471-2156/6/51 © 2005 Zhang and Sun; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Recent studies have indicated that the human genome could be divided into regions with low haplotype diversity interspersed with regions of high haplotype diversity. In regions of low haplotype diversity, a small fraction of SNPs (tag SNPs) are sufficient to account for most of the haplotype diversity of the human genome. These tag SNPs can be extremely useful for testing the