association between human cartilage glycoprotein 39 (ykl-40) and arterial stiffness in essential hypertension人类软骨糖蛋白39之间的联系(ykl-40)和原发性高血压动脉硬化.pdfVIP

Ma et al. BMC Cardiovascular Disorders 2012, 12:35 /1471-2261/12/35 RESEARCH ARTICLE Open Access Association between human cartilage glycoprotein 39 (YKL-40) and arterial stiffness in essential hypertension 1 2 1* 1 1 3 1 2* Wei-hong Ma , Xiu-ling Wang , Yi-meng Du , Yi-biao Wang , Yan Zhang , De-e Wei , Lin-lin Guo and Pei-Li Bu Abstract Background: YKL-40, a proposed marker of inflammation and endothelial dysfunction, is associated with atherosclerosis and an increased cardiovascular mortality in the general population. However, the relationship between YKL-40 and arterial stiffness in hypertensive patients has not been adequately assessed. Methods: The relationship between serum levels of YKL-40 and arterial stiffness was evaluated in 93 essential hypertensive subjects and 80 normal subjects. Essential hypertensive subjects were divided into two groups based upon urinary albumin-to-creatinine ratio (ACR): nonmicroalbuminuric group, (ACR 30 mg/g, n = 50) and microalbuminuric group (ACR ≥30 mg/g, n = 43). Large artery wall stiffness was assessed by measuring femoral arterial stiffness and carotid-femoral pulse wave velocity (cf-PWV). Serum levels of YKL-40 were determined by enzyme-linked immunosorbent assay (ELISA). Results: The study demonstrated that YKL-40,cf-PWV and femoral arterial stiffness were increased significantly (P0.05) in the hypertensive group compared with normal controls. These measurements were also increased significantly (P0.05) in the microalbuminuric group compared with the nonmicroalbuminuric group. YKL-40 was positively correlated with cf-PWV(r = 0.44, P = 0.000) and femoral arterial stiffness (r = 0.42, P =0.001). Multiple linear ste