association between the cytotoxic t-lymphocyte antigen 4 +49g a polymorphism and cancer risk a meta-analysis协会之间的细胞毒性t淋巴球抗原4 + 49 g多态性与癌症风险的荟萃分析.pdfVIP

Zheng et al. BMC Cancer 2010, 10:522 /1471-2407/10/522 RESEARCH ARTICLE Open Access Association between the Cytotoxic T-Lymphocyte Antigen 4 +49G A polymorphism and cancer risk: a meta-analysis 1† 1† 1 2 1 3 1* Jian Zheng , Xiao Yu , Lan Jiang , Mang Xiao , Bing Bai , Jiachun Lu , Yifeng Zhou Abstract Background: As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer risks, but previous results have been conflicting. Methods: We preformed a meta-analysis using 22 eligible case-control studies (including 32 datasets) with a total of 11,273 patients and 13,179 controls to summarize the existing data on the association between the CTLA-4 +49G A polymorphism and cancer risk. Results: Compared with the common CTLA-4 +49G A GG genotype, the carriers of variant genotypes (CTLA-4 +49 GC/CC) had a 1.24-fold elevated risk of cancer (95% CI = 1.18-1.32, P 0.05) under the dominant genetic model, as estimated using a fixed effect model. The effect of the CTLA-4 +49G A polymorphism was further evaluated using stratification analysis. In four breast cancer studies, patients with the variant genotypes had a significantly increased risk of breast cancer (OR = 1.31, 95% CI = 1.17-1.48, P 0.00001). A similar result was found in three skin cancer studies (OR = 1.30, 95% CI = 1.10-1.52, P = 0.001). In 26 solid tumor studies, subjects with the variant genotypes had a significantly higher risk of developing solid tumors (OR = 1.25, 95% CI = 1.18-1.33, P 0.00001) compared with the 6