association of hiv infection with distribution and viral load of hpv types in kenya a survey with 820 female sex workers协会的艾滋病毒感染人乳头状瘤病毒类型的分布和病毒载量在肯尼亚与820年的一项调查显示女性性工作者.pdfVIP

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association of hiv infection with distribution and viral load of hpv types in kenya a survey with 820 female sex workers协会的艾滋病毒感染人乳头状瘤病毒类型的分布和病毒载量在肯尼亚与820年的一项调查显示女性性工作者.pdf

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association of hiv infection with distribution and viral load of hpv types in kenya a survey with 820 female sex workers协会的艾滋病毒感染人乳头状瘤病毒类型的分布和病毒载量在肯尼亚与820年的一项调查显示女性性工作者

Luchters et al. BMC Infectious Diseases 2010, 10:18 /1471-2334/10/18 RESEARCH ARTICLE Open Access Association of HIV infection with distribution and viral load of HPV types in Kenya: a survey with 820 female sex workers 1,2 1,2 2,3* 4 2,8 Stanley MF Luchters , Davy Vanden Broeck , Matthew F Chersich , Annalene Nel , Wim Delva , Kishor Mandaliya5 6,7 2 6,7 2 , Christophe E Depuydt , Patricia Claeys , John-Paul Bogers , Marleen Temmerman Abstract Background: Human papillomavirus (HPV) and HIV are each responsible for a considerable burden of disease. Interactions between these infections pose substantial public health challenges, especially where HIV prevalence is high and HPV vaccine coverage low. Methods: Between July 2005 and January 2006, a cross-sectional community-based survey in Mombasa, Kenya, enrolled female sex workers using snowball sampling. After interview and a gynaecological examination, blood and cervical cytology samples were taken. Quantitative real-time PCR detected HPV types and viral load measures. Prevalence of high-risk HPV was compared between HIV-infected and -uninfected women, and in women with abnormal cervical cytology, measured using conventional Pap smears. Results: Median age of the 820 participants was 28 years (inter-quartile range [IQR] = 24-36 years). One third of women were HIV infected (283/803; 35.2%) and these women were y more likely to have abnormal cervical cytology than HIV-negative women (27%, 73/269, versus 8%, 42/503; P 0.001). Of HIV-infected women, 73.3% had high-risk HPV (200/273) and 35.5% had HPV 16 and