association of il-10 and il-10rβ gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an hla-identical sibling donor协会的il - 10和il-10rβ基因多态性与造血干细胞移植后移植物抗宿主病的病人一样同胞捐赠者.pdfVIP
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association of il-10 and il-10rβ gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an hla-identical sibling donor协会的il - 10和il-10rβ基因多态性与造血干细胞移植后移植物抗宿主病的病人一样同胞捐赠者
BMC Immunology BioMed Central
Research article Open Access
Association of IL-10 and IL-10Rβ gene polymorphisms with
graft-versus-host disease after haematopoietic stem cell
transplantation from an HLA-identical sibling donor
†1 †1 2 1
Jyrki Sivula , Hannu Turpeinen , Liisa Volin and Jukka Partanen*
Address: 1Research and Development, Finnish Red Cross Blood Service, Helsinki, Finland and 2Department of Medicine, Helsinki University
Central Hospital, Helsinki, Finland
Email: Jyrki Sivula - jyrki.sivula@helsinki.fi; Hannu Turpeinen - hannu.turpeinen@veripalvelu.fi; Liisa Volin - liisa.volin@hus.fi;
Jukka Partanen* - jukka.partanen@veripalvelu.fi
* Corresponding author †Equal contributors
Published: 4 May 2009 Received: 23 June 2008
Accepted: 4 May 2009
BMC Immunology 2009, 10:24 doi:10.1186/1471-2172-10-24
This article is available from: /1471-2172/10/24
© 2009 Sivula et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Extensive allelic matching in the human leukocyte antigen (HLA) genes is regarded
as a prerequisite for good clinical success of allogeneic haematopoietic stem cell transplantation
(HSCT). Also other genetic factors can
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