association of the matrix attachment region recognition signature with coding regions in caenorhabditis elegans关联矩阵的附件区域识别签名与编码地区线虫.pdfVIP

BMC Genomics BioMed Central Research article Open Access Association of the Matrix Attachment Region Recognition Signature with coding regions in Caenorhabditis elegans Alasdair Anthony* and Mark Blaxter Address: Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK Email: Alasdair Anthony* - al.anthony@ed.ac.uk; Mark Blaxter - mark.blaxter@ed.ac.uk * Corresponding author Published: 15 November 2007 Received: 4 May 2007 Accepted: 15 November 2007 BMC Genomics 2007, 8:418 doi:10.1186/1471-2164-8-418 This article is available from: /1471-2164/8/418 © 2007 Anthony and Blaxter; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Matrix attachment regions (MAR) are the sites on genomic DNA that interact with the nuclear matrix. There is increasing evidence for the involvement of MAR in regulation of gene expression. The unsuitability of experimental detection of MAR for genome-wide analyses has led to the development of computational methods of detecting MAR. The MAR recognition signature (MRS) has been reported to be associated with a significant fraction of MAR in C. elegans and has also been found in MAR from a wide range of other eukaryotes. However the effectiveness of the