原创力文档association studies of the copy-number variable ？-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis协会的研究人类基因组变量 -defensin集群p23.1 8日在腺癌和慢性胰腺炎.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
association studies of the copy-number variable ？-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis协会的研究人类基因组变量 -defensin集群p23.1 8日在腺癌和慢性胰腺炎
Taudien et al. BMC Research Notes 2012, 5:629
/1756-0500/5/629
RESEARCH ARTICLE Open Access
Association studies of the copy-number variable
ß-defensin cluster on 8p23.1 in adenocarcinoma
and chronic pancreatitis
1*† 2† 3† 1 3 1 3
Stefan Taudien , Gabor Gäbel , Oliver Kuss , Marco Groth , Robert Grützmann , Klaus Huse , Alexander Kluttig ,
4 4,8 5 3,6 7 4
Andreas Wolf , Michael Nothnagel , Philip Rosenstiel , Karin Halina Greiser , Karl Werdan , Michael Krawczak ,
Christian Pilarsky2 and Matthias Platzer1
Abstract
Background: Human ß-defensins are a family of antimicrobial peptides located at the mucosal surface. Both
sequence multi-site variations (MSV) and copy-number variants (CNV) of the defensin-encoding genes are
associated with increased risk for various diseases, including cancer and inflammatory conditions such as psoriasis
and acute pancreatitis. In a case–control study, we investigated the association between MSV in DEFB104 as well as
defensin gene (DEF) cluster copy number (CN), and pancreatic ductal adenocarcinoma (PDAC) and chronic
pancreatitis (CP).
Results: Two groups of PDAC (N=70) and CP (N=60) patients were compared to matched healthy control groups
CARLA1 (N=232) and CARLA2 (N=160), respectively. Four DEFB104 MSV were haplotyped by PCR, cloning and
sequencing. DEF cluster CN was determined by multiplex ligation-dependent probe amplification.
Neither the PDAC nor the CP cohorts show significant differences in the DEFB104 haplotype distribution compared
to the respective control groups CARLA1 and CARLA2, respectively.
您可能关注的文档
- assessing the evolutionary rate of positional orthologous genes in prokaryotes using synteny data评估位置同源基因在原核生物的进化速率使用同线性数据.pdf
- assessing the perceptions of a biostatistics and epidemiology module views ofyear 2 medical students from a malaysian university. a cross-sectional survey评估生物统计学和流行病学的感知模块视图ofyear 2马来西亚大学的医学院学生。.pdf
- assessing the ability of sequence-based methods to provide functional insight within membrane integral proteins a case study analyzing the neurotransmitterna+ symporter family评估的能力积分序列方法来提供功能的洞察力在膜蛋白质一个案例研究分析neurotransmitterna +同向转运的家庭.pdf
- assessing the feasibility of gs flx pyrosequencing for sequencing the atlantic salmon genome评估的可行性gs flx焦磷酸测序大西洋鲑鱼的基因组.pdf
- assessing the power of tag snps in the mapping of quantitative trait loci (qtl) with extremal and random samples评估标记snp的力量在映射的数量性状位点(qtl)定位与极值和随机样本.pdf
- assessing the joint effect of population stratification and sample selection in studies of gene-gene (environment) interactions评估人口分层和样本选择的联合效应的研究基因基因(环境)交互.pdf
- assessing the genomic evidence for conserved transcribed pseudogenes under selection评估选择下的守恒的转录基因证据伪基因.pdf
- assessing the role of undetected colonization and isolation precautions in reducing methicillin-resistant staphylococcus aureus transmission in intensive care units评估的作用未被发现的殖民和隔离预防措施在减少耐甲氧西林金黄色葡萄球菌传播在重症监护病房.pdf
- assessing the shape symbolism of the taste, flavour, and texture of foods and beverages评估的形状象征意义的味道,味道和质地的食物和饮料.pdf
- assessing the severity of conjunctivochalasis in a senile population a community-based epidemiology study in shanghai, china评估的严重性conjunctivochalasis在老年人口以社区为基础的流行病学研究在上海,中国.pdf
- association of the epstein-barr virus with breast cancer in vivo and in vitro studies协会与乳腺癌的巴尔病毒体内和体外研究.pdf
- associations between genetic variations in the furin gene and hypertensionfurin基因的遗传变异和高血压之间的联系.pdf
- associations among different functional and structural arterial wall properties and their relations to traditional cardiovascular risk factors in healthy subjects a cross-sectional study不同功能和结构之间的关联动脉壁属性及其关系与传统心血管危险因素在健康受试者的横断面研究.pdf
- associations between preschool attendance and developmental impairments in pre-school children in a six-year retrospective survey幼儿出勤和发育障碍之间的关联在学龄前儿童六年回顾性调查.pdf
- associations between lamb survival and prion protein genotype analysis of data for ten sheep breeds in great britain羊肉生存和朊蛋白基因型之间的关联数据分析十羊品种在英国.pdf
- associations between partial sickness benefit and disability pensions initial findings of a finnish nationwide register study之间的联系部分疾病补助费和残疾退休金的芬兰全国注册研究的初步结果.pdf
- associations between quality indicators of internal medicine residency training programs内科住院医师培训项目质量指标之间的关联.pdf
- association, effects and validation of polymorphisms within the ncapg - lcorl locus located on bta6 with feed intake, gain, meat and carcass traits in beef cattle协会、效果和验证ncapgu2014u2014lcorl内的多态性位点位于bta6采食量,增益,肉和牛肉胴体性状.pdf
- associations between statins and copd a systematic review他汀类药物之间的关联和慢性阻塞性肺病系统回顾.pdf
- associations between sexual behaviour change in young people and decline in hiv prevalence in zambia年轻人的性行为改变之间的联系和赞比亚艾滋病毒流行率下降.pdf
文档评论（0）