原创力文档attenuation of microvascular function in those with cardiovascular disease is similar in patients of indian asian and european descent微血管功能的衰减在那些有心血管疾病的病人相似的印度亚洲和欧洲血统.pdfVIP
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attenuation of microvascular function in those with cardiovascular disease is similar in patients of indian asian and european descent微血管功能的衰减在那些有心血管疾病的病人相似的印度亚洲和欧洲血统
Strain et al. BMC Cardiovascular Disorders 2010, 10:3
/1471-2261/10/3
RESEARCH ARTICLE Open Access
Attenuation of microvascular function in those
with cardiovascular disease is similar in patients
of Indian Asian and European descent
1* 2 2 2 2 2
William D Strain , Alun D Hughes , Jamil Mayet , Andrew R Wright , Jaspal Kooner , Nish Chaturvedi ,
Angela C Shore1
Abstract
Background: Indian Asians are at increased risk of cardiovascular death which does not appear to be explained by
conventional risk factors. As microvascular disease is also more prevalent in Indian Asians, and as it is thought to
play a role in the development of macrovascular disease, we decided to determine whether impaired
microcirculation could contribute to this increased cardiovascular risk in Indian Asians.
Methods: Forearm skin laser Doppler fluximetry in response to heating and ischaemia was assessed in 83
Europeans (41 with angiographically confirmed atherosclerotic coronary artery disease (CAD) and 42 from the
general population) and 84 Indian Asians (41 with CAD). Explanations for differences in microvascular function
were sought using multivariate analysis including conventional cardiovascular risk factors.
Results: Compared to ethnically matched control populations both Europeans and Indian Asians with CAD had
poorer microvascular responses to heating than those without (117(95% CI 105-131) vs. 142(130-162) arbitrary units,
(au) for Europeans and 111(101-122) vs. 141(131-153)au for Indian Asians) and to ischaemia (44(38-50) vs. 57(49-67)
au 39(34-45) vs. 49(43-56)au respectively). These differences were not accounted for by conventional
cardiovascular risk factors. There was no ethnic difference in the attenuation of m
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