原创力文档attenuation of circulatory shock and cerebral ischemia injury in heat stroke by combination treatment with dexamethasone and hydroxyethyl starch衰减的循环休克和脑缺血损伤与地塞米松联合治疗中暑的羟乙基淀粉.pdfVIP
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Yang et al. Experimental Translational Stroke Medicine 2010, 2:19
/content/2/1/19
RESEARCH Open Access
Attenuation of circulatory shock and cerebral
ischemia injury in heat stroke by combination
treatment with dexamethasone and hydroxyethyl
starch
1 2 3 4 4 4 4*
Tsai-Hsiu Yang , Mei-Fen Shih , Yi-Szu Wen , Wen-Yueh Ho , Kuen-Lin Leu , Mei-Ying Wang , Chia-Chyuan Liu
Abstract
Background: Increased systemic cytokines and elevated brain levels of monoamines, and hydroxyl radical
productions are thought to aggravate the conditions of cerebral ischemia and neuronal damage during heat
stroke. Dexamethasone (DXM) is a known immunosuppressive drug used in controlling inflammation, and
hydroxyethyl starch (HES) is used as a volume-expanding drug in cerebral ischemia and/or cerebral injury. Acute
treatment with a combined therapeutic approach has been repeatedly advocated in cerebral ischemia
experiments. The aim of this study is to investigate whether the combined agent (HES and DXM) has beneficial
efficacy to improve the survival time (ST) and heat stroke-induced cerebral ischemia and neuronal damage in
experimental heat stroke.
Methods: Urethane-anesthetized rats underwent instrumentation for the measurement of colonic temperature,
mean arterial pressure (MAP), local striatal cerebral blood flow (CBF), heart rate, and neuronal damage score. The
rats were exposed to an ambient temperature (43 degrees centigrade) to induce heat stroke. Concentrations of the
ischemic and damage markers, dopamine, serotonin, and hydroxyl radical productions in corpus striatum, and the
serum levels of interleukin-1 beta, tumor necrosis factor-alpha and malondialdehyde (MDA) were observed during
heat stroke.
R
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