automatic generation of 3d motifs for classification of protein binding sites自动生成3 d图案分类的蛋白质结合位点.pdfVIP

BMC Bioinformatics BioMed Central Research article Open Access Automatic generation of 3D motifs for classification of protein binding sites 1 2,3 2 Jean-Christophe Nebel* , Pawel Herzyk and David R Gilbert Address: 1Faculty of Computing, Information Systems Mathematics, Kingston University, Kingston-upon-Thames, KT1 2EE, UK, 2Bioinformatics Research Centre, University of Glasgow, Glasgow, G12 8QQ, UK and 3The Sir Henry Wellcome Functional Genomics Facility, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK Email: Jean-Christophe Nebel* - J.Nebel@kingston.ac.uk; Pawel Herzyk - ph53d@udcf.gla.ac.uk; David R Gilbert - drg@dcs.gla.ac.uk * Corresponding author Published: 30 August 2007 Received: 16 February 2007 Accepted: 30 August 2007 BMC Bioinformatics 2007, 8:321 doi:10.1186/1471-2105-8-321 This article is available from: /1471-2105/8/321 © 2007 Nebel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Since many of the new protein structures delivered by high-throughput processes do not have any known function, there is a need for structure-based prediction of protein function. Protein