原创力文档bioinformatics insights into acute lung injuryacute respiratory distress syndrome生物信息学见解急性肺injuryacute呼吸窘迫综合征.pdfVIP
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bioinformatics insights into acute lung injuryacute respiratory distress syndrome生物信息学见解急性肺injuryacute呼吸窘迫综合征
Fang et al. Clinical and Translational Medicine 2012, 1:9
/content/1/1/9
REVIEW Open Access
Bioinformatics insights into acute lung injury/
acute respiratory distress syndrome
1 1 1,2,3*
Xiaocong Fang , Chunxue Bai and Xiangdong Wang
Abstract
Bioinformatics is the application of omics science, information technology, mathematics and statistics in the field of
biomarker detection. Clinical bioinformatics can be applied for identification and validation of new biomarkers to
improve current methods of monitoring disease activity and identify new therapeutic targets. Acute lung injurt
(ALI)/Acute respiratory distress syndrome (ARDS) affects a large number of patients with a poor prognosis. The
present review mainly focused on the progress in understanding disease heterogeneity through the use of evolving
biological, genomic, and genetic approaches and the role of clinical bioinformatics in the pathogenesis and
treatment of ALI/ARDS. The remarkable advances in clinical bioinformatics can be a new way for understanding
disease pathogenesis, diagnosis and treatment.
Keywords: Acute lung injury, Acute respiratory distress syndrome, Genomics, Proteomics, Metabolomics,
Bioinformatics
Review pathologies), omics science, mathematics, information
Introduction technology and library data together. It may play a
In recent years, there is a great increase in genomics and potentially important role in the discovery of biomar-
other molecular research which produced a tremendous kers, which will facilitate the diagnosis of disease, as well
amount
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