原创力文档b-type natriuretic peptide and high sensitive c-reactive protein predict 2-year all cause mortality in chest pain patients a prospective observational study from salta, argentinab型利钠肽和高敏感的c反应蛋白预测2年胸痛患者的全因死亡率萨尔塔的前瞻性研究,阿根廷.pdfVIP
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b-type natriuretic peptide and high sensitive c-reactive protein predict 2-year all cause mortality in chest pain patients a prospective observational study from salta, argentinab型利钠肽和高敏感的c反应蛋白预测2年胸痛患者的全因死亡率萨尔塔的前瞻性研究,阿根廷
León de la Fuente et al. BMC Cardiovascular Disorders 2011, 11:57
/1471-2261/11/57
RESEARCH ARTICLE Open Access
B-type natriuretic peptide and high sensitive
C-reactive protein predict 2-year all cause
mortality in chest pain patients: a prospective
observational study from Salta, Argentina
1,2 2 3,4 2 3
Ricardo León de la Fuente , Patrycja A Naesgaard , Stein Tore Nilsen , Leik Woie , Torbjoern Aarsland ,
Patricio Gallo1, Heidi Grundt5,7, Harry Staines6 and Dennis WT Nilsen2,7*
Abstract
Background: Several mechanisms are involved in the pathophysiology of the Acute Coronary Syndrome (ACS). We
have addressed whether B-type natriuretic peptide (BNP) and high-sensitive C-reactive protein (hsCRP) in admission
samples may improve risk stratification in chest pain patients with suspected ACS.
Methods: We included 982 patients consecutively admitted with chest pain and suspected ACS at nine hospitals
in Salta, Northern Argentina. Total and cardiac mortality were recorded during a 2-year follow up period. Patients
were divided into quartiles according to BNP and hsCRP levels, respectively, and inter quartile differences in
mortality were statistically evaluated applying univariate and multivariate analyses.
Results: 119 patients died, and the BNP and hsCRP levels were significantly higher among these patients than in
survivors. In a multivariable Cox regression model for total death and cardiac death in all patients, the hazard ratio
(HR) in the highest quartile (Q4) as compared to the lowest quartile (Q1) of BNP was 2.32 (95% confidence interval
(CI), 1.24-4.35), p = 0.009 and 3.34 (95% CI, 1.26-8.85), p = 0.015, respectively. In the TnT positive patients (TnT
0.01 ng/mL), the HR for total dea
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