control of viral replication after cessation of haart控制病毒复制停止后的鸡尾酒疗法.pdfVIP

Van Gulck et al. AIDS Research and Therapy 2011, 8:6 /content/8/1/6 CASE REPORT Open Access Control of viral replication after cessation of HAART 1* 1 1 1 2 3 4 Ellen Van Gulck , Leo Heyndrickx , Lotte Bracke , Sandra Coppens , Eric Florence , Anne Buvé , Paul Lewi , Guido Vanham1,5 Abstract We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual “secondary controller” status. But their viruses are clearly less fit compared to viruses from rebounders. Introduction following criteria to define SC and rebounders: (1) being Highly active antiretroviral treatment (HAART) has HIV-1 infected for at least 3 years; (2) HAART started improved life expectancy and quality of life of HIV in the chronic progressive phase; (3) HAART discontin- infected patients [1]. However, so far it is not possible ued for the first time; and (4) VL below the detection to “cure” HIV infection mainly because latent reservoirs limit of 1.6log at treatment interruption. Pregnant persist even in patients who are on effective combina- women taking HAART to prevent mother-to-child tion treatment [2]. Cessation of HAART results in viral transmission and patients who started treatment in the rebound within days or weeks and pre-treatment le