conversion of amino-acid sequence in proteins to classical music search for auditory patterns蛋白质氨基酸序列转换成古典音乐搜索听觉模式.pdfVIP

Correspondence Conversion of amino-acid sequence in proteins to classical music: search for auditory patterns Rie Takahashi and Jeffrey H Miller Address: Department of Microbiology, Immunology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1489, USA. Correspondence: Rie Takahashi. Email: gene2music@ Published: 3 May 2007 Genome Biology 2007, 8:405 (doi:10.1186/gb-2007-8-5-405) The electronic version of this article is the complete one and can be found online at /2007/8/5/405 © 2007 BioMed Central Ltd Abstract We have converted genome-encoded protein sequences into musical notes to reveal auditory patterns without compromising musicality. We derived a reduced range of 13 base notes by pairing similar amino acids and distinguishing them using variations of three-note chords and codon distribu- tion to dictate rhythm. The conversion will help make genomic coding sequences more approach- able for the general public, young children, and vision-impaired scientists. In an effort to make science appealing “take root” [2]. Also, the Biochemist’s than looking at the coded information to a wider audience, interdisciplinary Songbook by Harold Baum describes per se . Moreover, the result creates a groups have combined efforts to initiate scientific concepts with lyrics and string of notes that has no recognizable novel approaches for the presentation song [3]. theme or musical depth as a compo- and perspective of scientific material. sition. Other attempts to convert DNA An example is that of Victor Wong, a In