原创力文档atriplaranti-tb combination in tbhiv patients. drug in focusatriplaranti-tb tbhiv患者的组合。.pdfVIP
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atriplaranti-tb combination in tbhiv patients. drug in focusatriplaranti-tb tbhiv患者的组合。
Semvua and Kibiki BMC Research Notes 2011, 4:511
/1756-0500/4/511
HYPOTHESIS Open Access
R
Atripla /anti-TB combination in TB/HIV patients.
Drug in focus
*
Hadija H Semvua and Gibson S Kibiki
Abstract
Background: Co-administration of anti-tuberculosis and antiretroviral therapy is often inevitable in high-burden
countries where tuberculosis is the most common opportunistic infection associated with HIV/AIDS. Concurrent use
of rifampicin and several antiretroviral drugs is complicated by pharmacokinetic drug-drug interaction.
Method: Pubmed and Google search following the key words tuberculosis, HIV, emtricitabine, tenofovir efavirenz,
interaction were used to find relevant information on each drug of the fixed dose combination AtriplaR
Results: Information on generic name, trade name, pharmacokinetic parameter, metabolism and the
pharmacokinetic interaction with Anti-TB drugs of emtricitabine, tenofovir, and efavirenz was obtained.
Conclusion: Fixed dose combination of emtricitabine/tenofovir/efavirenz (ATRIPLAR) which has been approved by
Food and Drug Administration shows promising results as far as safety and efficacy is concerned in TB/HIV co-
infection patients, hence can be considered effective and safe antiretroviral drug in TB/HIV management for adult
and children above 3 years of age.
Keywords: Tuberculosis, HIV, Emtricitabine, Tenofovir, Efavirenz, Interaction
Background tuberculosis in most resource limited settings is com-
Human immunodeficiency virus (HIV) and tuberculosis prised of a four-drug initial anti-tuberculosis regimen
(TB) are overlapping epidemics that cause an immense for 2 months (rifampicin, isoniazid, pyrazinamide a
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