原创力文档assessment of the effect of betaine on p16 and c-myc dna methylation and mrna expression in a chemical induced rat liver cancer model评估的影响甜菜碱p16和原癌基因dna甲基化和mrna表达化学诱导大鼠肝癌模型.pdfVIP
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assessment of the effect of betaine on p16 and c-myc dna methylation and mrna expression in a chemical induced rat liver cancer model评估的影响甜菜碱p16和原癌基因dna甲基化和mrna表达化学诱导大鼠肝癌模型
BMC Cancer BioMed Central
Database Open Access
Assessment of the effect of betaine on p16 and c-myc DNA
methylation and mRNA expression in a chemical induced rat liver
cancer model
2 2 3 1 1
Yan-ping Du , Jun-sheng Peng , Ai Sun , Zhi-hong Tang , Wen-hua Ling and
Hui-lian Zhu*1
Address: 1School of public health, Sun Yat-Sen University, 74th Zhongshan Road II, Guangzhou 510080, PR China, 2The 6th Affiliated Hospital
and Gastrointestinal Disease Institution, Sun Yat-Sen University, 26th Ruancun across-Road II, Guangzhou 510655, PR China and 3Guangzhou
health education institute, 92th Huijing Road, Guangzhou 510403, PR China
Email: Yan-ping Du - ypdu518@163.com; Jun-sheng Peng - pengjunsheng@; Ai Sun -; Zhi-
hong Tang - tangzhh@; Wen-hua Ling - lingwh@; Hui-lian Zhu* - zhuhl@
* Corresponding author
Published: 30 July 2009 Received: 12 October 2008
Accepted: 30 July 2009
BMC Cancer 2009, 9:261 doi:10.1186/1471-2407-9-261
This article is available from: /1471-2407/9/261
© 2009 Du et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The development and progression of liver cancer may involve abnormal changes in
DNA methylation, which lead to the activation
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