原创力文档atp-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytesmacrophagesatp-induced自噬与胞内分枝杆菌快速杀死人类monocytesmacrophages内.pdfVIP
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atp-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytesmacrophagesatp-induced自噬与胞内分枝杆菌快速杀死人类monocytesmacrophages内
BMC Immunology BioMed Central
Research article Open Access
ATP-induced autophagy is associated with rapid killing of
intracellular mycobacteria within human monocytes/macrophages
Debasis Biswas, Omar S Qureshi, Wing-Yiu Lee, Joanne E Croudace,
Manuela Mura and David A Lammas*
Address: Division of Immunity and Infection, The Medical School, University of Birmingham, B15 2TT, UK
Email: Debasis Biswas - dbiswas71@; Omar S Qureshi - o.qureshi@bham.ac.uk; Wing-Yiu Lee - wxl456@bham.ac.uk;
Joanne E Croudace - joannecroudace@; Manuela Mura - m.mura@bham.ac.uk; David A Lammas* - d.a.lammas@bham.ac.uk
* Corresponding author
Published: 15 July 2008 Received: 5 February 2008
Accepted: 15 July 2008
BMC Immunology 2008, 9:35 doi:10.1186/1471-2172-9-35
This article is available from: /1471-2172/9/35
© 2008 Biswas et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: We have previously reported that ATP treatment of M bovis-BCG infected human
macrophages induces P2X7 receptor-dependent killing of intracellular mycobacteria. The
mechanism mediating this bactericidal effect has not been full characterized but is known to be
Ca2+-dependent and to promote the maturation and acidification of mycobacteria-containing
phagosomes. In
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