cytotoxic triterpenoid saponins from the roots of platycodon grandiflorum细胞毒性桔梗根的三萜皂甙.pdfVIP
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cytotoxic triterpenoid saponins from the roots of platycodon grandiflorum细胞毒性桔梗根的三萜皂甙
Molecules 2007, 12, 832-841
molecules
ISSN 1420-3049
© 2007 by MDPI
/molecules
Full Paper
Cytotoxic Triterpenoid Saponins from the Roots of Platycodon
grandiflorum
Lin Zhang, Zhen-Huan Liu and Jing-Kui Tian*
Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University,
Hangzhou 310058, P. R. China; Tel: (+86)-571 Fax: (+86)-571
E-mail: zhanglin@ (Zhang)
* Author to whom correspondence should be addressed; E-mail: tjk@
Received: 30 January 2007; in revised form: 2 April 2007 / Accepted: 3 April 2007 / Published:
23 April 2007
Abstract: Bioguided fractionation of the ethanol extracts obtained from Platycodon
grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as
3-O-β-D-glucopyranosyl-2β,12α,16α,23,24-pentahydroxyoleanane-28(13)-lactone (1) and
3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-2β,12α,16α,23α-tetrahydroxyoleanane-
28(13)- lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both
compounds showed cytotoxic activity against human ECA-109 cells.
Keywords: Platycodon grandiflorum, Triterpenoid saponins, cytotoxic activity.
Introduction
The roots of Platycodon grandiflorum have been used as a traditional Chinese medicine as an
antiphlogistic, antitussive and expectorant [1]. This plant is well known to be abundant in triterpenoid
saponins, and 55 such compounds have been isolated from the genus [2-18]. Platicodins have been
found to exh
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