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design strategies of fluorescent biosensors based on biological macromolecular receptors设计策略的基于生物大分子受体荧光生物传感器.pdf

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design strategies of fluorescent biosensors based on biological macromolecular receptors设计策略的基于生物大分子受体荧光生物传感器

Sensors 2010, 10, 1355-1376; doi:10.3390/s100201355 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Review Design Strategies of Fluorescent Biosensors Based on Biological Macromolecular Receptors Kazuki Tainaka 1,2, Reiko Sakaguchi 1, Hironori Hayashi 1, Shun Nakano 1, Fong Fong Liew 1 and Takashi Morii 1,2,* 1 Institute of Advanced Energy, Kyoto University, Uji, Kyoto 611-0011, Japan; E-Mails: tainaka@iae.kyoto-u.ac.jp (K.T.); reiko@iae.kyoto-u.ac.jp (R.S.); h.hiro@iae.kyoto- u.ac.jp (H.H.); snaka@iae.kyoto-u.ac.jp (S.N.); fong-fong@iae.kyoto-u.ac.jp (F.F.L.) 2 CREST, JST, Uji, Kyoto 611-0011, Japan * Author to whom correspondence should be addressed; E-Mail: t-morii@iae.kyoto-u.ac.jp; Tel: +81-774-38-3585; Fax: +81-774-38-3516. Received: 5 January 2010; in revised form: 29 January 2010 / Accepted: 4 February 2010 / Published: 12 February 2010 Abstract: Fluorescent biosensors to detect the bona fide events of biologically important molecules in living cells are increasingly demanded in the field of molecular cell biology. Recent advances in the development of fluorescent biosensors have made an outstanding contribution to elucidating not only the roles of individual biomolecules, but also the dynamic intracellular relationships between these molecules. However, rational design strategies of fluorescent biosensors are not as mature as they look. An insatiable request for the establishment of a more universal and versatile strategy continues to provide