developments in the clinical understanding of lupus临床的发展对红斑狼疮的认识.pdfVIP

Available online /content/11/5/245 Review Developments in the clinical understanding of lupus Mary K Crow Autoimmunity and Inflammation Program, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA Corresponding author: Mary K Crow, crowm@ Published: 14 October 2009 Arthritis Research Therapy 2009, 11:245 (doi:10.1186/ar2762) This article is online at /content/11/5/245 © 2009 BioMed Central Ltd Abstract patients continues to improve, and the scope of clinical Advances in genetics and new understanding of the molecular research in search of new lupus therapies has significantly pathways that mediate innate and adaptive immune system expanded to include both traditional and new biologic agents. activation, along with renewed focus on the role of the complement system as a mediator of inflammation, have stimulated elaboration The etiopathogenesis of lupus comprises genetic contribu- of a scheme that might explain key mechanisms in the patho- tions, environmental triggers, and stochastic events, as genesis of systemic lupus erythematosus. Clinical observations demonstrated in murine models in the late 1980s [1]. These identifying important comorbidities in patients with lupus have been a recent focus of research linking immune mechanisms with clinical factors play out at the level of the immune system, with manifestations of disease. While these advances have identified multiple genetic hits and an undefined complement of rational and promising targ