原创力文档diagnosis of periarticular osteoporosis in rheumatoid arthritis using digital x-ray radiogrammetryperiarticular骨质疏松的诊断类风湿性关节炎使用数字x射线radiogrammetry.pdfVIP
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diagnosis of periarticular osteoporosis in rheumatoid arthritis using digital x-ray radiogrammetryperiarticular骨质疏松的诊断类风湿性关节炎使用数字x射线radiogrammetry
Available online /content/10/1/103
Editorial
Diagnosis of periarticular osteoporosis in rheumatoid arthritis
using digital X-ray radiogrammetry
Joachim Böttcher and Alexander Pfeil
Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Erlanger Allee, 07747 Jena, Germany
Corresponding author: Joachim Böttcher, joachim.boettcher@med.uni-jena.de
Published: 24 January 2008 Arthritis Research Therapy 2008, 10:103 (doi:10.1186/ar2352)
This article is online at /content/10/1/103
© 2008 BioMed Central Ltd
See related research article by Hoff et al., /content/9/4/R81
Abstract RA is a systemic inflammatory disease; in 80% of patients the
Osteoporosis can manifest in two ways in rheumatoid arthritis: small joints of the hand are affected, leading to destruction of
generalized bone loss, which may result from immobility, the periarticular tissue. The characteristic pattern of juxta-articular
inflammatory process per se and/or treatments such as steroids; inflammatory involvement includes cartilage destruction,
and periarticular demineralization, which is probably due to local periarticular osteoporosis and bone erosion [2].
release of inflammatory agents. Digital X-ray radiogrammetry (DXR)
is an effective and sensitive modality for monitoring periarticular
Many studies have revealed the influence of various cytokines
osteoporosis, which is among the earliest features of rheumatoid
arthritis, preceding bone erosions. DXR is a promising technique, on dysregulation of bone and cartilage remodelling. Recently,
which can provide quantitative data that allow early diagnosis. recept
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