dynamic interactions between t cells and dendritic cells and their derived cytokineschemokines in the rheumatoid synovium动态t细胞和树突细胞之间的相互作用及其派生类风湿性滑膜cytokineschemokines.pdfVIP

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dynamic interactions between t cells and dendritic cells and their derived cytokineschemokines in the rheumatoid synovium动态t细胞和树突细胞之间的相互作用及其派生类风湿性滑膜cytokineschemokines.pdf

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dynamic interactions between t cells and dendritic cells and their derived cytokineschemokines in the rheumatoid synovium动态t细胞和树突细胞之间的相互作用及其派生类风湿性滑膜cytokineschemokines

Available online /supplements/10/S1/S2 Review Dynamic interactions between T cells and dendritic cells and their derived cytokines/chemokines in the rheumatoid synovium Pierre Miossec Department of Immunology and Rheumatology, Hospital Edouard Herriot, University of Lyon, 69437 Lyon, France Corresponding author: Pierre Miossec, pierre.miossec@univ-lyon1.fr Published: 15 October 2008 Arthritis Research Therapy 2008, 10(Suppl 1):S2 (doi:10.1186/ar2413) This article is online at /supplements/10/S1/S2 © 2008 BioMed Central Ltd Abstract chymal cells, namely synoviocytes. Dendritic cells (DCs) play This review focuses on the contributions made by interactions a central role in the development of innate and adaptive between dendritic cells (DCs) and T cells, and by local production immune responses [3]. Both mature and immature DCs have of cytokines and chemokines to the pathogenesis of rheumatoid been identified in the lymphocytic infiltrates of the RA arthritis (RA) synovitis. DCs are efficient professional antigen- synovium, reflecting an ongoing immune-mediated reaction presenting cells, which are critical for the development of innate [4]. The review does not consider the possible antigen and adaptative immune responses through interactions with specificity of the response or the specific role played by B T cells. Cytokines from DCs play a key role in the switch inside effector T-cell pathways. Chemokines