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dietary phospholipids and intestinal cholesterol absorption饮食磷脂和肠内胆固醇的吸收
Nutrients 2010, 2, 116-127; doi:10.3390/nu2020116
OPEN ACCESS
nutrients
ISSN 2072-6643
/journal/nutrients
Article
Dietary Phospholipids and Intestinal Cholesterol Absorption
Jeffrey S. Cohn *, Alvin Kamili, Elaine Wat, Rosanna W. S. Chung and Sally Tandy
Nutrition and Metabolism Group, Heart Research Institute, 7 Eliza St. Newtown 2042 NSW, Sydney,
Australia; E-Mails: kamili@.au (A.K.); elaine.wat@ (E.W.);
chungr@.au (R.W.S.C.); tandys@.au (S.T.)
* Author to whom correspondence should be addressed: E-Mail: cohnj@.au;
Tel.: +612-8208-8906; Fax: +612-9565-5584.
Received: 27 November 2009 / Accepted: 29 January 2010 / Published: 8 February 2010
Abstract: Experiments carried out with cultured cells and in experimental animals have
consistently shown that phospholipids (PLs) can inhibit intestinal cholesterol absorption.
Limited evidence from clinical studies suggests that dietary PL supplementation has a
similar effect in man. A number of biological mechanisms have been proposed in order to
explain how PL in the gut lumen is able to affect cholesterol uptake by the gut mucosa.
Further research is however required to establish whether the ability of PLs to inhibit
cholesterol absorption is of therapeutic benefit.
Keywords: cardiovascular disease; cholesterol; intestine; micelle; phosphatidylcholine;
phosphatidylethanolamine; phospholipid; sphingomyelin
Abbreviations
HDL, high-density lipoprotein; LDL, low-density lipoprotein; lysoPC, lysophosp
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