guidelines for histopathological specimen examination and diagnostic reporting of primary bone tumours指导方针,组织病理学标本检查和诊断报告原发性骨肿瘤.pdfVIP

Mangham and Athanasou Clinical Sarcoma Research 2011, 1:6 /content/1/1/6 CLINICAL SARCOMA RESEARCH RESEARCH Open Access Guidelines for histopathological specimen examination and diagnostic reporting of primary bone tumours D Charles Mangham1 and Nicholas A Athanasou2* Abstract This review is intended to provide histopathologists with guidelines for clinical assessment, specimen handling and diagnostic reporting of benign and malignant primary bone tumours. Information from radiology, surgical, oncology and other clinical colleagues involved in the diagnosis and treatment of primary bone tumours should be properly assessed before undertaking a structured approach to specimen handling and histological reporting. This ensures that the information needed for planning appropriate treatment of these complex tumours is provided. Consistency in diagnostic evaluation with respect to both terminology and report content facilitates liaison at multidisciplinary bone tumour meetings and collaboration between cancer units and networks, as well as providing a common database for audit of the clinical, radiological and pathological aspects of bone tumours. 1. Introduction 2. Classification, grading staging of primary This review is intended to provide histopathologists with bone tumours guidelines for specimen handling and diagnostic report- Primary benign and malignant bone tumours vary ing of benign and malignant primary bone tumours; the widely in their clinical behaviour and pathological fea- principles of specimen handling required for assessment tures. The nomenclature and classification of primary of secondary bone tumours are similar. As many pr