high abundance synovial fluid proteome distinct profiles in health and osteoarthritis高丰富滑液蛋白质组截然不同的概要文件在健康和骨关节炎.pdfVIP

Available online /content/9/2/R36 Vol 9 No 2 Open Access Research article High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis 1 1 1 1 1 Reuben Gobezie , Alvin Kho , Bryan Krastins , David A Sarracino , Thomas S Thornhill , 1 1 1,2 Michael Chase , Peter J Millett and David M Lee 1The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA 2Department of Rheumatology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA Corresponding author: Reuben Gobezie, reuben.gobezie@ Received: 16 Jan 2007 Revisions requested: 8 Feb 2007 Revisions received: 6 Mar 2007 Accepted: 2 Apr 2007 Published: 2 Apr 2007 Arthritis Research Therapy 2007, 9:R36 (doi:10.1186/ar2172) This article is online at: /content/9/2/R36 © 2007 Gobezie et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The development of increasingly high-throughput and sensitive significantly differentially expressed between control individuals mass spectroscopy-based proteomic techniques provides new and OA patients. Two subsets of OA that are not dependent on opportunities to examine the physiology and pathophysiology of disease duration were identified using unsupe