原创力文档high dmbt1 concentrations in breast milk correlate with increased risk of infection in preterm and term neonates高dmbt1浓度母乳与感染风险增加早产和新生儿.pdfVIP
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high dmbt1 concentrations in breast milk correlate with increased risk of infection in preterm and term neonates高dmbt1浓度母乳与感染风险增加早产和新生儿
Ronellenfitsch et al. BMC Pediatrics 2012, 12:157
/1471-2431/12/157
RESEARCH ARTICLE Open Access
High DMBT1 concentrations in breast milk
correlate with increased risk of infection in
preterm and term neonates
1 2 1 1 3
Sebastian Ronellenfitsch , Christel Weiß , David Frommhold , Lutz Koch , Jan Mollenhauer ,
Johannes Poeschl 1 and Hanna Müller1*
Abstract
Background: Human milk contains immune molecules involved in the protection of newborns against infections.
We analyzed the concentration of Deleted in Malignant Brain Tumors 1 (DMBT1), a protein with functions in innate
immunity, in breast milk.
Methods: DMBT1 was detected in breast milk by Western blotting and its concentration was quantified by ELISA in
95 breast milk samples collected from mothers of preterm and term neonates during the first four weeks after
delivery. Possible effects of maternal or neonatal parameters were analyzed by different statistical tests.
Results: The mean DMBT1 concentration (± standard error of the mean) in the tested milk samples was
2.48 ± 0.26 μg/mL (range: 0.112 μg/mL to 17.984 μg/mL) and represented 0.0087% of the total protein content. The
comparison between the newborns with infection and the newborns without infection revealed significantly higher
DMBT1 concentrations in breast milk in the group with infection (6.72 ± 2.53 μg/mL versus 2.20 ± 0.35 μg/mL
(P = 0.031)). Neither maternal nor neonatal parameters showed a correlation with the milk DMBT1 levels.
Conclusions: DMBT1 is a component of breast milk after birth and is up-regulated in the breast milk from mothers
with newborns suffering from neonatal infection. Thus, breast milk DMBT1 may be part of the innate immunity
similar to secretory IgA.
Keywords: Breast mil
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