high central venous oxygen saturation in the latter stages of septic shock is associated with increased mortality中央静脉氧饱和度高的后期脓毒性休克与死亡率增加有关.pdfVIP
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high central venous oxygen saturation in the latter stages of septic shock is associated with increased mortality中央静脉氧饱和度高的后期脓毒性休克与死亡率增加有关
Textoris et al. Critical Care 2011, 15:R176
/content/15/4/R176
RESEARCH Open Access
High central venous oxygen saturation in the
latter stages of septic shock is associated with
increased mortality
*
Julien Textoris , Louis Fouché, Sandrine Wiramus, François Antonini, Sowita Tho, Claude Martin and Marc Leone
See related commentary by Haase and Perner, /content/15/4/184
Abstract
Introduction: Current guidelines recommend maintaining central venous oxygen saturation (ScvO ) higher than
2
70% in patients with severe sepsis and septic shock. As high levels of ScvO2 may reflect an inadequate use of
oxygen, our aim was to evaluate the relation between maximal ScvO2 levels (ScvO2max) and survival among
intensive care unit (ICU) patients with septic shock.
Methods: We retrospectively analyzed data from all admissions to our ICU between January 2008 and December
2009. All septic shock patients in whom the ScvO2 was measured were included. The measures of ScvO2max within
the first 72 hours after the onset of shock were collected.
Results: A total of 1,976 patients were screened and 152 (7.7%) patients met the inclusion criteria. The level of
ScvO2max was 85% (78 to 89) in the non-survivors, compared with 79% (72 to 87) in the survivors (P = 0.009).
Conclusions: Our findings raise concerns about high levels of ScvO2 in patients with septic shock. This may reflect
the severity of the shock with an impaired oxygen use. Future strategies may target an optimization of tissue
perfusion in this specific subgroup of patients.
Introduction of oxygen (mitochondrial dysfunction) and/or (iii) more
Shock
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