high cxcr3 expression in synovial mast cells associated with cxcl9 and cxcl10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis高cxcr3表达滑膜肥大细胞与cxcl9和cxcl10表达炎性滑膜组织的类风湿性关节炎患者.pdfVIP
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high cxcr3 expression in synovial mast cells associated with cxcl9 and cxcl10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis高cxcr3表达滑膜肥大细胞与cxcl9和cxcl10表达炎性滑膜组织的类风湿性关节炎患者
Available online /content/5/5/R241
Research article Open Access
High CXCR3 expression in synovial mast cells associated with
CXCL9 and CXCL10 expression in inflammatory synovial tissues
of patients with rheumatoid arthritis
1 2 3 2 1 4
Peter Ruschpler , Peter Lorenz , Wolfram Eichler , Dirk Koczan , Claudia Hänel , Roger Scholz ,
Christian Melzer5, Hans-Jürgen Thiesen2 and Peter Stiehl1
1Institute of Pathology, University of Leipzig, Leipzig, Germany
2Institute of Immunology, University of Rostock, Rostock, Germany
3Eye Hospital, University of Leipzig, Leipzig, Germany
4Department of Orthopedic Surgery, University of Leipzig, Leipzig, Germany
5Specialty Hospital of Orthopedic and Trauma Surgery, ‘Waldkrankenhaus’, Bad Düben, Germany
Correspondence: Peter Ruschpler (e-mail: rusp@medizin.uni-leipzig.de)
Received: 11 Nov 2002 Revisions requested: 8 Jan 2003 Revisions received: 6 May 2003 Accepted: 14 May 2003 Published: 26 Jun 2003
Arthritis Res Ther 2003, 5:R241-R252 (DOI 10.1186/ar783)
© 2003 Ruschpler et al., licensee BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362). This is an Open Access article: verbatim
copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original
URL.
Abstract
To improve our knowledge on the pathophysiology of CXCL10 (IFN-γ inducible protein 10) mRNAs, were significantly
rheumatoid arthritis (RA), we investigated gene expression upregulated in RA as compared with OA disease. Elevated
patterns in
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