high rates of albuminuria but not of low egfr in urban indigenous australians the druid study高蛋白尿但不低的表皮生长因子受体在城市土著澳大利亚人德鲁伊的研究.pdfVIP

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high rates of albuminuria but not of low egfr in urban indigenous australians the druid study高蛋白尿但不低的表皮生长因子受体在城市土著澳大利亚人德鲁伊的研究.pdf

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high rates of albuminuria but not of low egfr in urban indigenous australians the druid study高蛋白尿但不低的表皮生长因子受体在城市土著澳大利亚人德鲁伊的研究

Maple-Brown et al. BMC Public Health 2011, 11:346 /1471-2458/11/346 RESEARCH ARTICLE Open Access High rates of albuminuria but not of low eGFR in Urban Indigenous Australians: the DRUID Study 1,2* 1 3 4 5 Louise J Maple-Brown , Joan Cunningham , Allison M Hodge , Tarun Weeramanthri , Terry Dunbar , 2 6 7 8 6 9 Paul D Lawton , Paul Z Zimmet , Steve J Chadban , Kevan R Polkinghorne , Jonathan E Shaw and Kerin O’Dea Abstract Background: Indigenous Australians have an incidence of end stage kidney disease 8-10 times higher than non- Indigenous Australians. The majority of research studies concerning Indigenous Australians have been performed in rural or remote regions, whilst the majority of Indigenous Australians actually live in urban settings. We studied prevalence and factors associated with markers of kidney disease in an urban Indigenous Australian cohort, and compared results with those for the general Australian population. Methods: 860 Indigenous adult participants of the Darwin Region Urban Indigenous Diabetes (DRUID) Study were assessed for albuminuria (urine albumin-creatinine ratio≥2.5 mg/mmol males, ≥3.5 mg/mmol females) and low eGFR (estimated glomular filtration rate 60 mls/min/1.73 m2). Associations between risk factors and kidney disease markers were explored. Comparison was made with the AusDiab cohort (n = 8,936 aged 25-64 years), representative of the general Australian adult population. Results: A high prevalence of albuminuria (14.8%) was found in DRUID, whilst prevalence of low eGFR was 2.4%. Older age, higher HbA1c, hypert