high resolution discovery and confirmation of copy number variants in 90 yoruba nigerians高分辨率的拷贝数变异的发现和确认90年尼日利亚约鲁巴语.pdfVIP
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high resolution discovery and confirmation of copy number variants in 90 yoruba nigerians高分辨率的拷贝数变异的发现和确认90年尼日利亚约鲁巴语
Volume 10, Issue 11, Article R125Matsuzakiet al.2009 Open Access
Research
High resolution discovery and confirmation of copy number
variants in 90 Yoruba Nigerians
Hajime Matsuzaki, Pei-Hua Wang, Jing Hu, Rich Rava and Glenn K Fu
Address: Affymetrix, Inc., 3420 Central Expressway, Santa Clara, CA 95051, USA.
Correspondence: Glenn K Fu. Email: glenn_fu@
Published: 9 November 2009 Received: 20 May 2009
Revised: 4 September 2009
Genome Biology 2009, 10:R125 (doi:10.1186/gb-2009-10-11-r125)
Accepted: 9 November 2009
The electronic version of this article is the complete one and can be
found online at /2009/10/11/R125
© 2009 Matsuzaki et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MicroRNA regulatory effectspMost microRNAs have a stronger inhibitory effect in estrogen receptor-negative than in estrogen receptor-positive breast cancers./p
Abstract
Background: Copy number variants (CNVs) account for a large proportion of genetic variation
in the genome. The initial discoveries of long ( 100 kb) CNVs in normal healthy individuals were
made on BAC arrays and low resolution oligonucleotide arrays. Subsequent studies that used
higher resolution microarrays and SNP genotyping arrays detected the presence of large numbers
of CNVs that are 100 kb, with median lengths of approximately 10 kb. More recently, whole
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