histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption组蛋白脱乙酰酶抑制剂调节金属蛋白酶基因表达在软骨细胞和软骨吸收.pdfVIP

Available online /content/7/3/R503 Vol 7 No 3 Open Access Research article Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption 1,3 2 1 2 1 David A Young , Rachel L Lakey , Caroline J Pennington , Debra Jones , Lara Kevorkian , 1 2 1 Dylan R Edwards , Timothy E Cawston and Ian M Clark 1School of Biological Sciences, University of East Anglia, Norwich, UK 2Department of Rheumatology, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, UK 3Department of Rheumatology, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, UK Corresponding author: Ian M Clark, i.clark@uea.ac.uk Received: 11 Nov 2004 Revisions requested: 23 Dec 2004 Revisions received: 7 Jan 2005 Accepted: 25 Jan 2005 Published: 22 Feb 2005 Arthritis Research Therapy 2005, 7:R503-R512 (DOI 10.1186/ar1702) This article is online at: /content/7/3/R503 © 2005 Young et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Cartilage destruction in the arthritides is thought to be mediated collagenase activity assays using both SW1353 by two main enzyme families: the matrix metalloproteinases chondrosarcoma cells and primary human chondrocytes. The (MMPs) are responsible for