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hiv-1 virological synapse live imaging of transmissionhiv - 1病毒学突触传播实时成像
Viruses 2010, 2, 1666-1680; doi:10.3390/v2081666
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
HIV-1 Virological Synapse: Live Imaging of Transmission
Jerome Feldmann * and Olivier Schwartz *
Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France
* Authors to whom correspondence should be addressed;
E-Mails: jerome.feldmann@pasteur.fr (J.F.), olivier.schwartz@pasteur.fr (O.S.);
Tel.: +33-145-688-576 (J.F), Tel.: +33-145-688-353 (O.S.); Fax: +33-140-613-465 (O.S.).
Received: 15 July 2010; in revised form: 5 August 2010 / Accepted: 11 August 2010 /
Published: 12 August 2010
Abstract: A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells
by direct cellular contacts across a specialized structure, the virological synapse. This
process was recently described through live cell imaging. Together with the accumulated
knowledge on cellular and molecular structures involved in cell-to-cell transmission of
HIV-1, the visualization of the virological synapse in video-microscopy has brought
exciting new hypotheses on its underlying mechanisms. This review will recapitulate
current knowledge with a particular emphasis on the questions live microscopy has raised.
Keywords: HIV-1; virological synapse; live video-microscopy
1. Introduction: HIV-1 cell-to-cell transfer
Most viruses infect new target cells, and new hosts, by mean
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