horizontal gene transfer and the evolution of transcriptional regulation in escherichia coli水平基因转移和大肠杆菌的转录调控进化.pdfVIP

Volume 9, Issue 1, Article R4et al.Price2008 Open Access Research Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia coli Morgan N Price*†, Paramvir S Dehal*† and Adam P Arkin*†‡ Addresses: *Physical Biosciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 977-152, Berkeley, California 94720, USA. †Virtual Institute of Microbial Stress and Survival, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 977-152, Berkeley, California 94720, USA. ‡Department of Bioengineering, 1 Cyclotron Road, Mailstop 977-152, University of California, Berkeley 94720, California, USA. Correspondence: Morgan N Price. Email: morgannprice@ Published: 7 January 2008 Received: 4 August 2007 Revised: 6 November 2007 Genome Biology 2008, 9:R4 (doi:10.1186/gb-2008-9-1-r4) Accepted: 7 January 2008 The electronic version of this article is the complete one and can be found online at /2008/9/1/R4 © 2008 Price et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. within the E. coli lineage, as previously believed./pEvolution of transcriptional regulationpMost Escherichia coli transcription factors have paralogs, but these usually arose by horizontal gene transfer rather than by duplication Abstract Background: Most bacterial genes were acquired by horizontal gene transfer from other bacteria instead of being inherit