原创力文档high met gene copy number predicted poorprognosis in primary intestinal diffuse large b-celllymphoma高了基因拷贝数预测poorprognosis原发性肠道扩散大b-celllymphoma.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
high met gene copy number predicted poorprognosis in primary intestinal diffuse large b-celllymphoma高了基因拷贝数预测poorprognosis原发性肠道扩散大b-celllymphoma
Huang and Chuang Diagnostic Pathology 2013, 8:16
/content/8/1/16
RESEARCH Open Access
High MET gene copy number predicted poor
prognosis in primary intestinal diffuse large B-cell
lymphoma
Wan-Ting Huang1 and Shih-Sung Chuang2*
Abstract
Background: MET is a proto-oncogene with its copy number (CN) alterations been reported in some cancers, but
not in primary intestinal diffuse large B-cell lymphoma (PI-DLBL) yet.
Methods: In this retrospective study, we performed histology and chart reviews, immunohistochemistry and
quantitative polymerase chain reaction for MET CN alterations on 28 surgically resected PI-DLBLs.
Results: There were 12 men and 16 women with a median age of 70 and a mean follow-up of 32 months. The
median MET CN was 2.20 (range, 1.04 to 3.35). CN gain was observed in 11 cases, including 5 with CN greater than
3. Nine patients (32%) had diploid CN and eight (29%) with CN loss. Patients with gain or diploid CN showed
significantly worse prognosis (P = 0.046) than those with CN loss. Furthermore, MET CN greater than 3 was
associated with an adverse outcome (P = 0.003). Intestinal perforation at presentation was the sole
clinicopathological factor associated with a poor prognosis (P = 0.004) and perforation was correlated with CN
greater than 3 (P = 0.002).
Conclusions: Our finding of MET CN gain as a poor prognostic factor in PI-DLBL patients might serve as the
rationale for targeting MET signaling pathway in the treatment of these patients.
Keywords: Copy number, Diffuse large B-cell lymphoma, Intestine, MET, Primary intestinal diffuse large B-cell
lymphoma, Taiwan
Background tumorigenesis and invasion/metastasis by the following
Copy number alterations (CNAs) of genes are indica- cellular behaviors
您可能关注的文档
- correlation of microrna-372 upregulation with poor prognosis in human glioma相关的微rna - 372 upregulation人类神经胶质瘤预后不良.pdf
- 'correction' serum transforming growth factor beta-1 (tgf-beta-1) levels in diabetic patients are not associated with pre-existent coronary artery diseaseu201c修正u201d血清转化生长因子beta 1(tgf-beta-1)水平在糖尿病患者并不与预先存在冠状动脉疾病有关.pdf
- covariances entre apparentés quelconques avec linkage et épistasie. ii. – évolution en régime d'autofécondation协方差之间明显quelconques et epistasie用的联系。.pdf
- cough are children really different to adults咳嗽的孩子真的不同于成人.pdf
- conversion of amino-acid sequence in proteins to classical music search for auditory patterns蛋白质氨基酸序列转换成古典音乐搜索听觉模式.pdf
- critical care canada forum 2008, 11–13 november 2008, toronto, ontario, canada急救护理加拿大论坛2008年,2008年11月11 - 13日,多伦多,加拿大安大略省.pdf
- crop breeding for low input agriculture a sustainable response to feed a growing world population作物育种低投入农业可持续应对满足不断增长的世界人口.pdf
- crystal structure of n,n,n’,n’-tetra-[(3,5-dimethyl-1-pyrazolyl) methyl]-para-phenylenediamine晶体结构的n,n,n ',n '四-[(3 5-dimethyl-1-pyrazolyl)甲基]-para-phenylenediamine.pdf
- cytokine mrna and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis细胞因子mrna和蛋白表达在初代培养和repeated-passage从类风湿性关节炎患者滑膜成纤维细胞.pdf
- cytotoxic triterpenoid saponins from the roots of platycodon grandiflorum细胞毒性桔梗根的三萜皂甙.pdf
- high level expression of acidothermus cellulolyticus β-1, 4-endoglucanase in transgenic rice enhances the hydrolysis of its straw by cultured cow gastric fluid高水平表达acidothermus cellulolyticusβ-1 4-endoglucanase在转基因水稻提高水解的稻草培养牛胃液体.pdf
- high functionalization of 5-nitro-1h-imidazole derivatives the tdae approach高功能化tdae 5-nitro-1h-imidazole衍生品的方法.pdf
- high mcm3 expression is an independent biomarker of poor prognosis and correlates with reduced rbm3 expression in a prospective cohort of malignant melanoma高mcm3表达式是一个独立的不良预后的生物标志物和与减少rbm3表达式前瞻性群组的恶性黑色素瘤.pdf
- high mixed venous oxygen saturation levels do not exclude fluid responsiveness in critically ill septic patients高混合静脉氧饱和度水平不排除在重症败血症的病人对液体的反应.pdf
- high levels of rna-editing site conservation amongst 15 laboratory mouse strains高水平的rna编辑网站保护在15个实验室老鼠菌株.pdf
- high maternal mortality in rural south-west ethiopia estimate by using the sisterhood method高孕产妇死亡率在埃塞俄比亚西南部农村估计通过姐妹关系的方法.pdf
- high mobility group box 1 (hmgb1) and anti-hmgb1 antibodies and their relation to disease characteristics in systemic lupus erythematosus高机动组框1(hmgb1)和anti-hmgb1抗体及其关系在系统性红斑狼疮疾病特征.pdf
- high frequency of phenotypic deviations in physcomitrella patens plants transformed with a gene-disruption library高频率的表型偏差physcomitrella金属盘植物基因破坏图书馆转变.pdf
- high molecular weight glucan of the culinary medicinal mushroom agaricus bisporus is an α-glucan that forms complexes with low molecular weight galactan高分子量葡聚糖的烹饪药用蘑菇双孢菇的α-glucan形式与低分子量半乳糖体复合物.pdf
- high potential of escalating hiv transmission in a low prevalence setting in rural tanzania不断升级的艾滋病毒传播的高潜力低流行率设定在农村坦桑尼亚.pdf
文档评论（0）