原创力文档high mobility group box 1 (hmgb1) and anti-hmgb1 antibodies and their relation to disease characteristics in systemic lupus erythematosus高机动组框1(hmgb1)和anti-hmgb1抗体及其关系在系统性红斑狼疮疾病特征.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
high mobility group box 1 (hmgb1) and anti-hmgb1 antibodies and their relation to disease characteristics in systemic lupus erythematosus高机动组框1(hmgb1)和anti-hmgb1抗体及其关系在系统性红斑狼疮疾病特征
Abdulahad et al. Arthritis Research Therapy 2011, 13:R71
/content/13/3/R71
RESEARCH ARTICLE Open Access
High mobility group box 1 (HMGB1) and
anti-HMGB1 antibodies and their relation
to disease characteristics in systemic
lupus erythematosus
*
Deena A Abdulahad , Johanna Westra, Johannes Bijzet, Pieter C Limburg, Cees GM Kallenberg and Marc Bijl
Abstract
Introduction: High Mobility Group Box 1 (HMGB1) is a nuclear non-histone protein. HMGB1, which is secreted by
inflammatory cells and passively released from apoptotic and necrotic cells, may act as a pro-inflammatory
mediator. As apoptotic cells accumulate in systemic lupus erythematosus (SLE), HMGB1 levels might be increased
in SLE. HMGB1 may also serve as an autoantigen, leading to the production of anti-HMGB1 antibodies. In this study
we determined levels of HMGB1 and anti-HMGB1 in SLE patients in comparison to healthy controls (HC) and
analysed their relation with disease activity.
Methods: The study population consisted of 70 SLE patients and 35 age- and sex-matched HC. Thirty-three SLE
patients had quiescent disease, the other 37 patients were selected for having active disease. Nineteen of these
had lupus nephritis. HMGB1 levels were measured with both Western blot and ELISA. Anti-HMGB1 levels were
measured by ELISA. Clinical and serological parameters were assessed according to routine procedures.
Results: HMGB1 levels in SLE patients could be measured reliably by Western blotting only, and were significantly
increased compared to HC. During active disease HMGB1 levels increased, in particular in patients with renal
involvement. Serum HMGB1 levels correlated with SLEDAI, proteinuria, and anti-dsDNA levels, and showed a
negative correlation with complement C3. Anti-HMGB1 levels were significantly increased in SLE patients compared
您可能关注的文档
- cough are children really different to adults咳嗽的孩子真的不同于成人.pdf
- conversion of amino-acid sequence in proteins to classical music search for auditory patterns蛋白质氨基酸序列转换成古典音乐搜索听觉模式.pdf
- critical care canada forum 2008, 11–13 november 2008, toronto, ontario, canada急救护理加拿大论坛2008年,2008年11月11 - 13日,多伦多,加拿大安大略省.pdf
- crop breeding for low input agriculture a sustainable response to feed a growing world population作物育种低投入农业可持续应对满足不断增长的世界人口.pdf
- crystal structure of n,n,n’,n’-tetra-[(3,5-dimethyl-1-pyrazolyl) methyl]-para-phenylenediamine晶体结构的n,n,n ',n '四-[(3 5-dimethyl-1-pyrazolyl)甲基]-para-phenylenediamine.pdf
- cytokine mrna and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis细胞因子mrna和蛋白表达在初代培养和repeated-passage从类风湿性关节炎患者滑膜成纤维细胞.pdf
- cytotoxic triterpenoid saponins from the roots of platycodon grandiflorum细胞毒性桔梗根的三萜皂甙.pdf
- cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis巨细胞病毒激活和相关危重严重脓毒症患者的结果.pdf
- axon-bearing and axon-less horizontal cell subtypes are generated consecutively during chick retinal development from progenitors that are sensitive to follistatinaxon-bearing期间生成的连续和axon-less水平细胞亚型鸡视网膜发展u2014u2014卵泡敏感,过分生长的祖细胞.pdf
- cytoprotective efficacy of amifostine against radiation- induced rectal toxicity objective and subjective grading scales for radiomucositiscytoprotective amifostine对抗辐射的功效,引起直肠毒性radiomucositis客观和主观评分尺度.pdf
- high frequency of phenotypic deviations in physcomitrella patens plants transformed with a gene-disruption library高频率的表型偏差physcomitrella金属盘植物基因破坏图书馆转变.pdf
- high molecular weight glucan of the culinary medicinal mushroom agaricus bisporus is an α-glucan that forms complexes with low molecular weight galactan高分子量葡聚糖的烹饪药用蘑菇双孢菇的α-glucan形式与低分子量半乳糖体复合物.pdf
- high potential of escalating hiv transmission in a low prevalence setting in rural tanzania不断升级的艾滋病毒传播的高潜力低流行率设定在农村坦桑尼亚.pdf
- high mobility group box protein 1 in complex with lipopolysaccharide or il-1 promotes an increased inflammatory phenotype in synovial fibroblasts高机动组盒蛋白1在复杂与脂多糖或il - 1促进增加炎性滑膜成纤维细胞表型.pdf
- high precision signal processing algorithm for white light interferometry白光干涉法的高精度信号处理算法.pdf
- high molecular mass proteomics analyses of left ventricle from rats subjected to differential swimming training高分子量的蛋白质组学分析从大鼠左心室进行微分游泳训练.pdf
- high prevalence of hiv infection among homeless and street-involved aboriginal youth in a canadian setting盛行的艾滋病毒感染中无家可归,street-involved原住民青年在加拿大环境.pdf
- high prevalence of overweight among adolescents in ho chi minh city, vietnam超重的青少年在胡志明市,越南.pdf
- high prevalence of autoantibodies to rna helicase a in mexican patients with systemic lupus erythematosus自身抗体的rna解旋酶在墨西哥系统性红斑狼疮患者.pdf
- high mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes高机动组框1强化interleukin-1β的促炎作用在骨关节炎synoviocytes.pdf
文档评论（0）