原创力文档high prevalence of autoantibodies to rna helicase a in mexican patients with systemic lupus erythematosus自身抗体的rna解旋酶在墨西哥系统性红斑狼疮患者.pdfVIP
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high prevalence of autoantibodies to rna helicase a in mexican patients with systemic lupus erythematosus自身抗体的rna解旋酶在墨西哥系统性红斑狼疮患者
Vázquez-Del Mercado et al. Arthritis Research Therapy 2010, 12:R6
/content/12/1/R6
RESEARCH ARTICLE Open Access
High prevalence of autoantibodies to RNA
helicase A in Mexican patients with systemic
lupus erythematosus
1,2 1 1 3
Monica Vázquez-Del Mercado , Claudia A Palafox-Sánchez , Jose F Muñoz-Valle , Gerardo Orozco-Barocio ,
Edith Oregon-Romero1 1 4 5
, Rosa E Navarro-Hernández , Mario Salazar-Páramo , Juan Armendariz-Borunda ,
4 6 7 8 7,9*
Jorge I Gámez-Nava , Laura Gonzalez-Lopez , Jason YF Chan , Edward KL Chan , Minoru Satoh
Abstract
Introduction: Autoantibodies to RNA helicase A (RHA) were reported as a new serological marker of systemic
lupus erythematosus (SLE) associated with early stage of the disease. Anti-RHA and other autoantibodies in
Mexican SLE patients and their correlation with clinical and immunological features were examined.
Methods: Autoantibodies in sera from 62 Mexican SLE patients were tested by immunoprecipitation of 35S-labeled
K562 cell extract and enzyme-linked immunosorbent assay (anti-U1RNP/Sm, ribosomal P, b2GPI, and dsDNA). Anti-
RHA was screened based on the immunoprecipitation of the 140-kDa protein, the identity of which was verified by
Western blot using rabbit anti-RHA serum. Clinical and immunological characteristics of anti-RHA-positive patients
were analyzed.
Results: Anti-RHA was detected in 23% (14/62) of patients, a prevalence higher than that of anti-Sm (13%, 8/62).
Prevalence and levels of various autoanti
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