原创力文档high prevalence of lipoatrophy in pre-pubertal south african children on antiretroviral therapy a cross-sectional study脂肪萎缩pre-pubertal南非孩子的横断面研究抗逆转录病毒治疗.pdfVIP
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high prevalence of lipoatrophy in pre-pubertal south african children on antiretroviral therapy a cross-sectional study脂肪萎缩pre-pubertal南非孩子的横断面研究抗逆转录病毒治疗
Innes et al. BMC Pediatrics 2012, 12:183
/1471-2431/12/183
RESEARCH ARTICLE Open Access
High prevalence of lipoatrophy in pre-pubertal
South African children on antiretroviral therapy:
a cross-sectional study
1* 1 2 3 4 5
Steve Innes , Mark F Cotton , Richard Haubrich , Maria M Conradie , Margaret van Niekerk , Clair Edson ,
5 6 6 7 3 8*
Helena Rabie , Sonia Jain , Xiaoying Sun , Ekkehard W Zöllner , Stephen Hough and Sara H Browne
Abstract
Background: Despite changes in WHO guidelines, stavudine is still used extensively for treatment of pediatric HIV
in the developing world. Lipoatrophy in sub-Saharan African children can be stigmatizing and have far-reaching
consequences. The severity and extent of lipoatrophy in pre-pubertal children living in sub-Saharan Africa is
unknown.
Methods: In this cross-sectional study, children who were 3-12 years old, on antiretroviral therapy and pre-pubertal
were recruited from a Family HIV Clinic in South Africa. Lipoatrophy was identified and graded by consensus
between two HIV pediatricians using a standardized grading scale. A professional dietician performed formal dietary
assessment and anthropometric measurements of trunk and limb fat. Previous antiretroviral exposures were
recorded. In a Dual-Energy X-ray Absorbtiometry (DXA) substudy body composition was determined in 42
participants.
Results: Among 100 recruits, the prevalence of visually obvious lipoatrophy was 36% (95% CI: 27%–45%).
Anthropometry and DXA measurements corroborated the clinical diagnosis of lipoatrophy: Both confirmed
significant, su
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