high mobility group box-1 protein in patients with suspected community-acquired infections and sepsis a prospective study高机动组盒1蛋白在疑似社区获得性感染和脓毒症患者的前瞻性研究.pdfVIP

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high mobility group box-1 protein in patients with suspected community-acquired infections and sepsis a prospective study高机动组盒1蛋白在疑似社区获得性感染和脓毒症患者的前瞻性研究.pdf

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high mobility group box-1 protein in patients with suspected community-acquired infections and sepsis a prospective study高机动组盒1蛋白在疑似社区获得性感染和脓毒症患者的前瞻性研究

Available online /content/11/2/R32 Vol 11 No 2 Open Access Research High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study 1 1 2 1 Shahin Gaïni , Svend Stenvang Pedersen , Ole Græsbøll Koldkjær , Court Pedersen and Holger Jon Møller3 1Department of Infectious Diseases, Odense University Hospital, Søndre Boulevard 29, DK-5000 Odense C, Denmark 2Department of Clinical Biochemistry, Sønderborg Hospital, Sydvang 1, DK-6400 Sønderborg, Denmark 3Department of Clinical Biochemistry, Aarhus University Hospital, Nørrebrogade 44, DK-8000 Aarhus C, Denmark Corresponding author: Shahin Gaïni, shahin.gaini@ouh.fyns-amt.dk Received: 29 Dec 2006 Revisions requested: 7 Feb 2007 Revisions received: 16 Feb 2007 Accepted: 8 Mar 2007 Published: 8 Mar 2007 Critical Care 2007, 11:R32 (doi:10.1186/cc5715) This article is online at: /content/11/2/R32 © 2007 Gaïni et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Sepsis is a serious condition with a significant Results One hundred and ninety-four patients were included in morbidity and mortality. New insight into the the study. Levels of HMGB1 are presented as medians and immunopathogenesis of sepsis could promote the development interquartile ran