high grade angiosarcoma arising in fibroadenoma优质纤维腺瘤所引起的血管肉瘤.pdfVIP

Babarović et al. Diagnostic Pathology 2011, 6:125 /content/6/1/125 CASE REPORT Open Access High grade angiosarcoma arising in fibroadenoma 1* 1 1 2 Emina Babarović , Gordana Zamolo , Elvira Mustać and Miroslav Strčić Abstract Primary angiosarcoma of the breast is a rare tumour that account for fewer than 0.05% of all malignant mammary tumours. Angiosarcoma may have an perfidious clinical onset. Radiologic findings are often nonspecific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor because of the high rates of local recurrence and early development of metastases. Aggressive surgical resection is the mainstay of treatment. The role of adjuvant therapy has not yet been well established. Here we present a case of a 53 year old, postmenopausal women with primary angiosarcoma arising in fibroadenoma. To our knowledge, this is the first case described in the literature to date. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/1812981492621981. Keywords: Breast, fibroadenoma, primary angiosarcoma, mastectomy Background comparison, primary angiosarcomas are relatively rarer, Angiosarcoma is a rare malignancy of endovascular ori- they tipically occurs in younger women and arise from gin. Skin and superficial soft tissue are the most com- breast parenchyma. Secondary angiosarcomas usually mon locations that become involved. This is in contrast occurs in elderly women, arise from skin and show a with the deeper location of other soft tissue sarcomas. pattern