intervertebral disc cells as competent phagocytes in vitro implications for cell death in disc degeneration椎间盘细胞主管吞噬细胞在体外对细胞死亡在椎间盘变性的影响.pdfVIP

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intervertebral disc cells as competent phagocytes in vitro implications for cell death in disc degeneration椎间盘细胞主管吞噬细胞在体外对细胞死亡在椎间盘变性的影响.pdf

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intervertebral disc cells as competent phagocytes in vitro implications for cell death in disc degeneration椎间盘细胞主管吞噬细胞在体外对细胞死亡在椎间盘变性的影响

Available online /content/10/4/R86 Vol 10 No 4 Open Access Research article Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration 1,2 1,2 1 2 1,2 Philip Jones , Lucy Gardner , Janis Menage , Gwyn T Williams and Sally Roberts 1Centre for Spinal Studies, Robert Jones Agnes Hunt Orthopaedic District Hospital NHS Trust, Oswestry, Shropshire SY10 7AG, UK 2Institute of Science and Technology in Medicine, Keele University, Keele, Staffordshire, ST5 5BG, UK Corresponding author: Sally Roberts, sally.roberts@rjah.nhs.uk Received: 8 Apr 2008 Revisions requested: 23 May 2008 Revisions received: 19 Jun 2008 Accepted: 1 Aug 2008 Published: 1 Aug 2008 Arthritis Research Therapy 2008, 10:R86 (doi:10.1186/ar2466) This article is online at: /content/10/4/R86 © 2008 Jones et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Apoptosis has been reported to occur in the Results Disc cells were able to ingest latex beads at least as intervertebral disc. Elsewhere in the body, apoptotic cells are efficiently, if not more so, than phagocytic THP-1 and J774 cells. cleared from the system via phagocytosis by committed Disc cells ingested a greater number of beads per cell than the phagocytes such as macrophages, reducing the chance of committed phagocytes in a similar time scale. In addition, di