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host genetic variants in the pathogenesis of hepatitis c宿主的遗传变异在丙型肝炎的发病机制
Viruses 2012, 4, 3281-3302; doi:10.3390/v4 123281
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
Host Genetic Variants in the Pathogenesis of Hepatitis C
Monika Rau 1, Katharina Baur 2 and Andreas Geier 1,2,*
1 Division of Hepatology, Department of Internal Medicine II, University Hospital Würzburg,
Oberdürrbacherstraße 6, 97080 Würzburg, Germany; E-Mail: rau_m@medizin.uni-wuerzburg.de
2 Department of Gastroenterology and Hepatology, University Hospital Zurich, Rämistrasse 100,
8091 Zurich, Switzerland; E-Mail: kathrin_baur@
* Author to whom correspondence should be addressed;
E-Mail: geier_a2@medizin.uni-wuerzburg.de; Tel.: +49-931-201-40201;
Fax: +49-931-201-640201.
Received: 26 October 2012; in revised form: 17 November 2012 / Accepted: 17 November 2012 /
Published: 22 November 2012
Abstract: Direct-acting antiviral drugs (DAAs) are currently replacing antiviral therapy for
Hepatitis C infection. Treatment related side effects are even worse and the emergence of
resistant viruses must be avoided because of the direct-antiviral action. Altogether it
remains a challenge to take treatment decisions in a clinical setting with cost restrictions.
Genetic host factors are hereby essential to implement an individualized treatment concept.
In recent years results on different genetic variants have been published with a strong
association with therapy response, fibrosis and treatment-related side effects.
Polymorphisms of the IL28B gene
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