原创力文档intestinal microflora and body mass index during the first three years of life an observational study肠道微生物区系和身体质量指数在生命的头三年一项观察性研究.pdfVIP
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intestinal microflora and body mass index during the first three years of life an observational study肠道微生物区系和身体质量指数在生命的头三年一项观察性研究
Vael et al. Gut Pathogens 2011, 3:8
/content/3/1/8
RESEARCH Open Access
Intestinal microflora and body mass index during
the first three years of life: an observational study
1*† 2† 3 1 2
Carl Vael , Stijn L Verhulst , Vera Nelen , Herman Goossens and Kristine N Desager
Abstract
Background: Recent research on obesity has demonstrated that the intestinal microflora can have an important
influence on host energy balance. The aim of the study was to investigate the relationship between the intestinal
microflora and the body mass index in the first 3 years of life.
Results: In a prospective study, a faecal sample from 138 infants was taken at the age of 3, 26 and 52 weeks and
cultured on selective media for 6 bacterial genera. Between the age of 1 and 3 years the Body Mass Index
Standard Deviation Score (BMI SDS) of these children was determined. The association between the intestinal flora
and BMI SDS was assessed for each bacterial genus. A positive correlation was found between the Bacteroides
fragilis concentration and the BMI SDS at the age of 3 and 26 weeks. The Staphylococcus concentration showed a
negative correlation with the BMI SDS at the age of 3 and 52 weeks. A low intestinal ratio of Staphylococcus/
Bacteroides fragilis at the age of 3 weeks, corresponding to a low Staphylococcus and a high Bacteroides fragilis
concentration, was associated with a higher BMI SDS during the first three years of life.
Conclusion: High intestinal Bacteroides fragilis and low Staphylococcus concentrations in infants between the age
of 3 weeks and 1 year were associated with a higher risk of obesity later in life. This study could provide new
targets for a better and more effective modulation of the i
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