原创力文档hospitalised neonates in estonia commonly receive potentially harmful excipients一般住院新生儿在爱沙尼亚获得潜在的有害辅料.pdfVIP
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hospitalised neonates in estonia commonly receive potentially harmful excipients一般住院新生儿在爱沙尼亚获得潜在的有害辅料
Lass et al. BMC Pediatrics 2012, 12:136
/1471-2431/12/136
RESEARCH ARTICLE Open Access
Hospitalised neonates in Estonia commonly
receive potentially harmful excipients
1,2* 3 4 5 6 7,8 1
Jana Lass , Kaisa Naelapää , Utpal Shah , Ruth Käär , Heili Varendi , Mark A Turner and Irja Lutsar
Abstract
Background: Information on the neonatal exposure to excipients is limited. Our aim was to describe the extent of
excipient intake by Estonian neonates; to classify the excipients according to potential neonatal toxicity and thereby
to measure the extent of exposure of neonates to potentially harmful excipients.
Methods: A prospective cohort study that recorded all medicines prescribed to patients aged below 28 days
admitted to Tartu University Hospital from 01.02-01.08 2008 and to Tallinn Children’s Hospital from 01.02- 01.08
2009 was conducted. Excipients were identified from Summaries of Product Characteristics and classified according
to toxicity following a literature review.
Results: 1961 prescriptions comprising 107 medicines were written for 348/490 neonates admitted. A total of 123
excipients were found in 1620 (83%) prescriptions and 93 (87%) medicines. 47 (38%) of these excipients were
classified as potentially or known to be harmful to neonates. Most neonates (97%) received at least one medicine
(median number 2) with potentially or known to be harmful excipient. Parabens were the most commonly used
known to be harmful excipients and sodium metabisulphite the most commonly used potentially harmful
excipient, received by 343 (99%) and 297 (85%) of treated neonates, respectively.
Conclusions: Hospitalised neonates in Estonia are commonly receiving a wide range of excipients wit
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