原创力文档intraoperative 3-d mapping of parathyroid adenoma using freehand spect术中三维映射使用徒手spect的甲状旁腺腺瘤.pdfVIP
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intraoperative 3-d mapping of parathyroid adenoma using freehand spect术中三维映射使用徒手spect的甲状旁腺腺瘤
Rahbar et al. EJNMMI Research 2012, 2:51
/content/2/1/51
PRELIMINARY RESEARCH Open Access
Intraoperative 3-D mapping of parathyroid
adenoma using freehand SPECT
1* 2 2 1 1
Kambiz Rahbar , Mario Colombo-Benkmann , Christina Haane , Christian Wenning , Alexis Vrachimis ,
Matthias Weckesser1 and Otmar Schober1
Abstract
Background: Freehand single photon emission computed tomography (fSPECT) is a three-dimensional (3-D)
tomographic imaging modality based on data acquisition with a handheld detector that is moved freely, in
contrast to conventional, gantry-mounted gamma camera systems. In this pilot study, we evaluated the feasibility of
fSPECT for intraoperative 3-D mapping in patients with parathyroid adenomas.
Methods: Three patients (range 30 to 45 years) diagnosed with hyperparathyroidism (one primary and two tertiary)
underwent parathyroid scintigraphy with technetium-99m sestamibi (99mTc-MIBI) to localize parathyroid adenomas.
Two patients were referred with persistent hyperparathyroidism after conventional parathyroidectomy. In all three
patients, a planar scintigraphy of the neck was performed 10 min after injection (p.i.) followed by SPECT/CT (Symbia
T2, Siemens Healthcare) and a correlative ultrasound 2 h p.i. 99mTc-MIBI scan was performed the day before surgery
in two patients and at the same day in one patient. fSPECT images were acquired intraoperatively using declipse
SPECT (SurgicEyeTM).
Results: A total of five parathyroid adenomas were successfully located with SPECT/CT. fSPECT allowed
intraoperative detection of all adenomas, and successful parathyroidectomy was accomplished. Parathyroid
hormone level decreased intraoperatively in all three patients, on average, by 79% (range 72%
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