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Allergy, Asthma Clinical
Immunology BioMed Central
Review Open Access
How safe are the biologicals in treating asthma and rhinitis?
Linda S Cox
Address: Department of Medicine, Nova Southeastern University Osteopathic College of Medicine, Fort Lauderdale, Florida, USA
Email: Linda S Cox - Lindaswolfcox@
Published: 22 October 2009 Received: 1 October 2009
Accepted: 22 October 2009
Allergy, Asthma Clinical Immunology 2009, 5:4 doi:10.1186/1710-1492-5-4
This article is available from: /content/5/1/4
© 2009 Cox; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
A number of biological agents are available or being investigated for the treatment of asthma and
rhinitis. The safety profiles of these biologic agents, which may modify allergic and immunological
diseases, are still being elucidated. Subcutaneous allergen immunotherapy, the oldest biologic agent
in current use, has the highest of frequency of the most serious and life-threatening reaction,
anaphylaxis. It is also one of the only disease modifying interventions for allergic rhinitis and asthma.
Efforts to seek safer and more effective allergen immunotherapy treatment have led to
investigati
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