high-mobility group box protein 1 (hmgb1) an alarmin mediating the pathogenesis of rheumatic disease高机动组盒蛋白1(hmgb1)alarmin调解风湿性疾病的发病机理.pdfVIP

Available online /content/10/3/209 Review High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease David S Pisetsky1,2, Helena Erlandsson-Harris3 and Ulf Andersson4 1Division of Rheumatology and Immunology, Duke University Medical Center, Durham, NC, USA 2Medical Research Service, Durham Veterans Administration Medical Center 3Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet/Karolinska University Hospital L8:04, Stockholm S-171 76, Sweden 4Department of Medicine, Rheumatology Unit, Karolinska Institutet/Karolinska University Hospital Q2:09, Stockholm S-171 76, Sweden Corresponding author: David S Pisetsky, dpiset@ Published: 30 June 2008 Arthritis Research Therapy 2008, 10:209 (doi:10.1186/ar2440) This article is online at /content/10/3/209 © 2008 BioMed Central Ltd Abstract During the past decade, studies in both patients and animal High-mobility group box protein 1 (HMGB1) is a non-histone models have established the alarmin activity of HMGB1 in nuclear protein that has a dual function. Inside the cell, HMGB1 acute and chronic inflammatory conditions, including the binds DNA, regulating transcription and determining chromosomal rheumatic diseases. Since HMGB1 may be a target of new architecture. Outside the cell, HMGB1 can serve as an alarmin to therapy, HMGB1 biology has emerged as a rapidly expanding activate the innate system and mediate a wide range of physio- field of both basic and clinical research. This review will logical and pathological responses. To functio