molecular therapies for systemic lupus erythematosus clinical trials and future prospects分子治疗系统性红斑狼疮的临床试验和未来前景.pdfVIP

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molecular therapies for systemic lupus erythematosus clinical trials and future prospects分子治疗系统性红斑狼疮的临床试验和未来前景.pdf

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molecular therapies for systemic lupus erythematosus clinical trials and future prospects分子治疗系统性红斑狼疮的临床试验和未来前景

Available online /content/11/3/234 Review Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects Fanny Monneaux and Sylviane Muller CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67000 Strasbourg, France Corresponding author: Sylviane Muller, S.Muller@ibmc.u-strasbg.fr Published: 30 June 2009 Arthritis Research Therapy 2009, 11:234 (doi:10.1186/ar2711) This article is online at /content/11/3/234 © 2009 BioMed Central Ltd Abstract such as azathioprine, methotrexate, cyclophosphamide, and The prognosis of patients with systemic lupus erythematosus has cyclosporine, and more recently by the use of mycophenolate greatly improved since treatment regimens combining cortico- mofetil (CellCept) that appears effective with fewer side steroids and immunosuppressive medications have been widely effects. At present, antimalarials (hydroxychloroquine), adopted in therapeutic strategies given to these patients. Immune corticosteroids and cytotoxic drugs are classically used as suppression is evidently efficient but also leads to higher medication in SLE. It has to be recognized, however, that susceptibility to infectious and malignant diseases. Toxic effects significant well-known adverse effects of these conventional and sometimes unexpectedly dramatic complications of current therapies have been progressively reported. Identifying nove