interleukin-6 discovery of a pleiotropic cytokine多效性的细胞因子白细胞介素- 6的发现.pdfVIP

Available online /content/8/S2/S2 Proceedings Interleukin-6: discovery of a pleiotropic cytokine Tadamitsu Kishimoto Laboratory of Immunoregulation, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan Corresponding author: Tadamitsu Kishimoto, kishimot@imed3.med.osaka-u.ac.jp Published: 28 July 2006 Arthritis Research Therapy 2006, 8(Suppl 2):S2 This article is online at /content/8/S2/S2 (doi:10.1186/ar1916) © 2006 BioMed Central Ltd Abstract Discovery of interleukin-6 In 1986 one of these factors was cloned and studied, and it In the late 1960s, the essential role played by T cells in antibody production was reported. This led to our hypothesis that certain is now referred to as IL-6. This molecule possesses a wide molecules would have to be released from T cells to effect the range of activities, and as a result laboratories used various stimulation of B cells. This hypothesis was shown to be true. There different names to refer to it, depending on their research were certain factors present in the culture supernatant of T cells interests. It has been termed B cell stimulatory factor-2 and that induced proliferation and differentiation of B cells. The factor was considered a novel IFN (IFN-β2), but studies with that induced B cells to produce immunoglobulins was initially named B cell stimulatory factor-2. The cDNA encoding the human recombinant IL-6 and anti-IL-6 antibody demonstrated that B cell stimulatory factor-2 was cloned in 1986.